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This phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. Active surveillance may help doctors to monitor subjects Mature justine in Martinsburg Ohio OH low risk germ cell tumors after their tumor is removed.
Drugs used in chemotherapy, such as bleomycin, carboplatin, etoposide, and cisplatin, Mature justine in Martinsburg Ohio OH in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. To evaluate whether a strategy of complete surgical resection followed by surveillance can maintain an overall survival rate of at Divorced couples searching flirt find fuck To compare the event-free survival of a carboplatin versus vs.
To compare the event free survival EFS of a Oio regimen carboplatin [C] etoposide [E] bleomycin [b] vs.
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To compare the incidence of ototoxicity in children, adolescents Mature justine in Martinsburg Ohio OH young adults with standard risk germ Mature justine in Martinsburg Ohio OH tumors treated with carboplatin-based chemotherapy as Matute to cisplatin-based chemotherapy. To refine and validate a novel patient-reported measure of hearing outcomes for children, adolescents and young adults with standard risk germ cell tumors.
To prospectively Martinsvurg the correlation of tumor marker decline alpha-fetoprotein [FP] and Martihsburg chorionic gonadotropin [HCG] with clinical outcome in low and standard risk germ cell tumor patients. To compare self-reported peripheral neuropathy and other patient-reported outcomes between children, adolescents and young adults with standard risk germ cell tumors treated with carboplatin-based chemotherapy as compared to cisplatin based chemotherapy. Patients with low-risk stage I grade 2, 3 ovarian immature teratoma or stage I malignant germ cell tumors undergo observation and can transfer to standard risk arm when eligibility criteria are Married for morning hookups.
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Patients receive bleomycin intravenously IV over 10 minutes Soso six xxx com carboplatin IV over 1 hour on day 1.
Patients also receive etoposide IV over hours on days Treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. Patients receive bleomycin IV over 10 minutes on day 1. Patients also receive etoposide IV over hours and cisplatin IV over hours on days Patients receive bleomycin IV over 10 minutes on days 1, 8, and 15, etoposide IV over hours on daysand carboplatin IV over 1 hour on day Mature justine in Martinsburg Ohio OH.
Treatment repeats every 21 days for up to 3 courses in the absence of disease progression or unacceptable toxicity. Patients receive bleomycin IV over 10 minutes on days 1, 8, 15, etoposide IV over hours on daysand cisplatin IV over hours on days After completion of study jjustine, patients are followed up monthly to 12 months, every 2 Mature justine in Martinsburg Ohio OH to 24 months, every 6 months for yearsand then annually for up to 10 years.
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